2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. LIM Kinase (LIMK)

LIM Kinase (LIMK)

LIMKs

LIM Kinase (LIMK)

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LIM kinases (LIMKs) are important cell cytoskeleton regulators that play a prominent role in cancer manifestation and neuronal diseases. The LIMK family consists of two homologues, LIMK1 and LIMK2, which differ from one another in expression profile, intercellular localization, and function. The main substrate of LIMK is cofilin, a member of the actin-depolymerizing factor (ADF) protein family. When phosphorylated by LIMK, cofilin is inactive. LIMKs play a contributory role in several neurodevelopmental disorders and in cancer growth and metastasis.

LIM domain kinases (LIMK1 and 2) are substrate for Cdc42/Rac-PAK, and modulate actin dynamics by phosphorylating cofilin at serine-3. This modification inactivates cofilin’s actin severing and depolymerizing activity. LIMKs also translocate into the nucleus and regulate cell cycle progression. LIMKs are potential therapeutic targets for NF2 and other merlin-deficient tumors.

LIM Kinase (LIMK) Isoform Specific Products:

LIM Kinase (LIMK) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-136849
    TL13-68
    		Inhibitor 98.31%
    TL13-68 is a biotin-tagged version of SM1-71, and it can be used to research the mechanism of SM1-71.
    TL13-68
  • HY-174229
    SM311
    		Inhibitor
    SM311 (Compound 10), a chemical probe, is a potent selective irreversible LIMK1 inhibitor (EC50=0.045 μM, >30-fold selective over LIMK2). SM311 blocks cofilin phosphorylation and actin cytoskeleton regulation. SM311 is promising for research of neurodegenerative diseases like Fragile X syndrome (FXS) and Alzheimer’s disease, as well as tumor invasion.
    SM311
  • HY-W070753
    LIMK1 inhibitor 2
    		Inhibitor 98.74%
    LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with the IC50 of 9 μM.
    LIMK1 inhibitor 2
  • HY-178122
    THNAN69
    		Degrader
    THNAN69 is a potent chemical probe degrader targeting LIMK2, with a DC50 value of 1 nM. THNAN69 can be used for the study of diseases driven by LIMK2 overexpression or dysregulation, such as cancers and ocular diseases.
    THNAN69
  • HY-N10868
    8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide
    		Inhibitor
    8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, has anti-LIMK1 activity. 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide has inhibitory property on cell motility.
    8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide
  • HY-14226
    LIMK-IN-3
    		Inhibitor
    LIMK-IN-3 (Compound 33) is a LIMK2 inhibitor (IC50: 1.2 nM). LIMK-IN-3 can be used for glaucoma research.
    LIMK-IN-3
  • HY-168908
    LIJTF500025
    		Inhibitor
    LIJTF500025, a chemical probe, is a potent and selective LIMK inhibitor, with pIC50 values of 6.77 and 7.03 for LIMK1 and LIMK2, respectively, as determined by NanoBRET. LIJTF500025 can be used for the research of cancer.
    LIJTF500025
  • HY-RS07663
    Limk1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Limk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Limk1 Mouse Pre-designed siRNA Set A
  • HY-159897
    PAK4-IN-5
    		Inhibitor
    PAK4-IN-5 (Compound 12i) is a PAK4 inhibitor (IC50: 7.68 nM for PAK4, 1872.01 nM for PAK1). PAK4-IN-5 binds to PAK4 stably via multiple interactions. PAK4-IN-5 inhibits the proliferation and the migratory potential of MDA-MB-231 cells by inhibiting the phosphorylation of PAK4 and LIMK1. PAK4-IN-5 arrests cell cycle in the G0/G1 phase, induces apoptosis and ROS production. LD50: >500 mg/kg for mice (p.o.).
    PAK4-IN-5
  • HY-RS07667
    Limk2 Rat Pre-designed siRNA Set A
    		Inhibitor

    Limk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Limk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Limk2 Rat Pre-designed siRNA Set A
  • HY-RS07666
    Limk2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Limk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Limk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Limk2 Mouse Pre-designed siRNA Set A
  • HY-135843
    TH-263
    		Control 99.0%
    TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257.
    TH-263
  • HY-E70841
    LIMK2 Recombinant Human Active Protein Kinase
    LIM kinase 2 (LIMK2) is a serine/threonine and tyrosine kinases. LIMK2 plays a crucial role in the regulation of cytoskeleton dynamics by controlling actin filaments and microtubule turnover, especially through the phosphorylation of cofilin, an actin depolymerising factor. LIMK2 Recombinant Human Active Protein Kinase is a recombinant LIMK2 protein that can be used to study LIMK2-related functions.
    LIMK2 Recombinant Human Active Protein Kinase
  • HY-175656
    MDI-117740
    		Inhibitor
    MDI-117740 is a dual LIMK1/2 inhibitor. MDI-117740 shows effective cellular target engagement with LIMK1 (pIC50 = 6.73) and LIMK2 (pIC50 = 7.18) in HEK293 cells. MDI-117740 exerts significant anti-migratory activity in MDA-MB-231 cells. MDI-117740 can be used for the study of cancers and neurodegenerative disorders.
    MDI-117740
  • HY-123345
    CRT 0105446
    		Inhibitor
    CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC50 of 8 nM.
    CRT 0105446
  • HY-N8669
    Curcolonol
    		Inhibitor
    Curcolonol is a furan type sesquiterpene. Curcolonol can be isolated from several medical herbs. Curcolonol has inhibitory activity for LIM kinase 1. Curcolonol can be used for the research of breast cancer.
    Curcolonol
  • HY-RS07665
    LIMK2 Human Pre-designed siRNA Set A
    		Inhibitor

    LIMK2 Human Pre-designed siRNA Set A contains three designed siRNAs for LIMK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    LIMK2 Human Pre-designed siRNA Set A
  • HY-161417
    LIMK-IN-2
    		Inhibitor
    LIMK-IN-2 (Compound 52) is an LIMK inhibitor. LIMK-IN-2 can suppress the cell migration of osteosarcoma and cervical cancer cells, demonstrating potential anti-angiogenic activity.
    LIMK-IN-2
  • HY-144438
    Aurora/LIM kinase-IN-1
    		Inhibitor
    Aurora/LIM kinase-IN-1 (Compound F114) is a potent and dual inhibitor of aurora and lim kinase. Aurora kinases and lim kinases are involved in neoplastic cell division and cell motility, respectively. Aurora/LIM kinase-IN-1 inhibits GBM proliferation and invasion. Aurora/LIM kinase-IN-1 is a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future agent development efforts for GBM, and potentially other cancers.
    Aurora/LIM kinase-IN-1
  • HY-RS07664
    Limk1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Limk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Limk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Limk1 Rat Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
LIM Kinase (LIMK) Isoform Comparison

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